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Undergraduate
Courses
Graduate Courses
Official Yale College program and course information is found in Yale College Programs of Study, available at http://yalecollege.yale.edu/content/yale-college-programs-study
Courses in MDCB 2012-2103
Note: The letter "a" following a course number indicates a fall term course; "b" indicates a spring term course; "G" indicates courses offered to undergraduate and graduate students; courses without an "a" or "b" are year-long; “*” indicates permission from the instructor is needed. Bracketed courses are not offered in the academic year 2012-2013.
Undergraduate
Courses
REQUIRED: NEW INTRODUCTORY COURSES
BIOL 101a. Biochemistry and Biophysics. Michael Koelle
M W 11.35-12.50, 1 HTBA
Introduction to the study of life at the molecular level. Topics include the three-dimensional structures and function of large biological molecules, the human genome, and the design of antiviral drugs to treat HIV/AIDS. Prerequisite: The first of four modules in a yearlong introductory biology sequence; meets for the first half of the fall term.
BIOL 102a. Principles of Cell Biology and Membrane Physiology. Mark Mooseker
M W 11.35-12.50, 1 HTBA
Introduction to the study of cell biology and membrane physiology. Topics include organization and functional properties of biological membranes, membrane physiology and signaling, rough endoplasmic reticulum and synthesis of membrane/secretory membrane proteins, endocytosis, the cytoskeleton, and cell division. Prerequisite: The second of four modules in a yearlong introductory biology sequence; meets for the second half of the fall term.
BIOL 103b. Genes and Development. Frank Slack
T Th 11.35-12.50, 1 HTBA
Introduction to genes, genetics, and developmental biology. How genes control development and disease; Mendel's rules; examples of organ physiology. Prerequisite: The third of four modules in a yearlong introductory biology sequence; meets for the first half of the spring term.
BIOL 104b. Principles of Ecology and Evolutionary Biology. Leo Buss
T Th 11.35-12.50, 1 HTBA
Introduction to ecology, evolutionary biology, animal behavior, and the history of life. Evolutionary transitions and natural selection. Adaptation at genic, chromosomal, cellular, organismal, and supra-organismal levels. Distributional and social consequences of particular suites of organismal adaptations. Prerequisite: The fourth of four modules in a yearlong introductory biology sequence; meets for the second half of the spring term.
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INTRODUCTORY
COURSES WITHOUT PREREQUISITES:
MCDB 103b. Cancer. Alexia Belperron
MW 1.00-2.15
Introduction to the biology of cancer, with a focus on leukemia, skin cancer, and cancers linked to infection. Topics include genetics, biochemistry, immunity, infection agents, and challenges for prevention and treatment. Intended for non–science majors and underclassmen.
MCDB 105a or b/MB&B 105a or b. An Issues Approach to Biology.
105a: Timothy Nelson, William Summers, David Wells
105b: Dieter Söll, Martin Garcia-Castro
MW 11.35-12.25 1 HTBA
Biological concepts taught in context of current societal issues, such as stem cell research and genetically modified organisms. Emphasis on biological literacy to enable students to evaluate scientific arguments.
MCDB 106a&b/HLTH 155a&b. Biology of Malaria, Lyme, and Other Vector-Borne Diseases. Alexia Belperron
MW 1.00-2.15
Introduction to the biology of pathogen transmission from one organism to another by insects; special focus on malaria and Lyme disease. Modes of transmission and establishment of infection; immune responses and the associated challenges to prevention and treatment and the development of vaccines. Intended for non–science majors. Prerequisite: high school biology.
[*MCDB 107a. Human Biology]
*MCDB 109b. Immunity and Contagion. Paula Kavathas
TTh 2.30-3.455 Meets RP
Introduction to the human immune system, followed by study of microorganisms such as influenza, HIV, human papilloma virus, Chlamydia trachomatis, and human microbiota. Discussion of the biology of each organism and interaction with the host immune system, reinforcing principles of immune function. Enrollment limited to freshmen and sophomores.
MCDB 123b. Genes and Environment. Jo Handelsman
MW 10.30-11.20 & T 2.30-3.20
The nature of biological thought and inquiry explored through study of the interplay between genes and the environment. Influence of the microbial world on the physiology and evolution of organisms. Tools from molecular biology and genomics are used to examine the effects of internal and external factors on gene expression, how the process of gene expression leads to observable characteristics, and the relationship between bacterial gene expression and human survival.
[*MCDB 135b/*CGSC 202b. How the Brain Works. David Wells, Mitchell Kundel]
MCDB 150bG/HIST 400b. Global Problems of Population Growth. Robert Wyman
MW 2.30-3.45
The worldwide population explosion in its human, environmental, and economic dimensions.
Sociobiological bases of reproductive behavior. Population history and the cause of demographic change. Interactions of population growth with economic development and environmental alteration. Political, religious, and ethical issues surrounding fertility; human rights and the status of women.
MCDB 166 . From Microbes to Molecules. Jo Handelsman, Carol Bascom-Slack
MWF 9.25-11.20
A yearlong introduction to biology and chemistry through research on soil bacteria. Focus on the discovery of antibiotics from soil bacteria isolated from the Yale campus. Diversity of life, structure of biomolecules, components of a cell, molecular basis of gene expression, heritability, and symbiosis. Comparison with eukaryotic molecular and cellular biology. Enrollment restricted to freshmen.
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MCDB
CORE COURSES
Choose One From Each Category Below (3 total)
MCDB 200b or MCDB 202a
MCDB 205b or MCDB 210b
MCDB 300b or MBB 300a
MCDB 200b. Molecular Biology. Stephen Dellaporta, Anna Pyle, Farren Isaacs
MWF 11.35-12.50
A study of the fundamental principles of molecular biology, including the experimental methodologies used in biological research. Topics include the structure, function, and chemical behavior of biological macromolecules (DNA, RNA, and protein), chromosome and genome organization, replication and maintenance of the genome, transcriptional and translational regulation, microRNAs and other noncoding RNAs, RNA processing, and systems biology. Designed to provide an accelerated venue for MCDB majors and other students seeking to understand the molecular basis for gene expression and biological function. Prerequisite: CHEM 112 and 113, or 114 and 115, or 118, or a score of 5 on the Advanced Placement test in Biology, or BIOL 101 or equivalent performance on the corresponding biological sciences placement examination; or with permission of instructor.
MCDB 202a. Genetics. Stephen Dellaporta, Martín García-Castro, Murat Acar
TTh 11.35-12.50
An introduction to classical, molecular, and population genetics of both prokaryotes and eukaryotes and their central importance in biological sciences. Emphasis on analytical approaches and techniques of genetics used to investigate mechanisms of heredity and variation. Topics include transmission genetics, cytogenetics, DNA structure and function, recombination, gene mutation, selection, and recombinant DNA technology. Prerequisite: BIOL 103or equivalent performance on the corresponding biological sciences placement examination. .
MCDB 205b. Cell Biology. Thomas Pollard, Valerie Horsley, Megan King
TTh 9-10.15
A comprehensive introductory course in cell biology. Emphasis on the general principles that explain the molecular mechanisms of cellular function. Prerequisite: BIOL 101 and 102, or equivalent performance on the corresponding biological sciences placement examinations, or a score of 5 on the Advanced Placement test in Biology, or a score of 710 or above on the SAT Biology M test, or MCDB 200.
MCDB 210b. Developmental Biology. Vivian Irish, Scott Holley, Douglas Kankel
TTh 11.35-12.50
Cellular differentiation and its genetic and molecular control; fertilization, cleavage, and morphogenesis of plants and animals; polarity and positional information; organogenesis and development of specialized tissues; evolution and development. Prerequisites: BIOL 101, 102, and 103, or equivalent performance on the corresponding biological sciences placement examinations.
MCDB 300bG/MB&B 200b. Biochemistry. Ronald Breaker, Donald Engelman
MWF 9.25-10.15
An introduction to the biochemistry of animals, plants, and microorganisms, emphasizing the relations of chemical principles and structure to the evolution and regulation of living systems. Prerequisites: BIOL 101, 102, 103, and 104, or equivalent performance on the corresponding biological sciences placement examinations; one term of organic chemistry; or with permission of instructor.
MBB 300aG. Principles of Biochemistry I. Thomas Biederer, Michael Koelle
TTh 11.35-12.50
Discussion of the physical, structural, and functional properties of proteins, lipids, and carbohydrates, three major classes of molecules in living organisms. Energy metabolism, hormone signaling, and muscle contraction as examples of complex biological processes whose underlying mechanisms can be understood by identifying and analyzing the molecules responsible for these phenomena. After BIOL 101; after or concurrently with CHEM 125 or 220
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MCDB LABORATORIES
MCDB 121La. Molecular Cellular Developmental Biology Lab. Maria Moreno
TWThF 1:30-5:30
An introduction to biological research with an emphasis on the utility of model organisms. Exercises in basic molecular biology techniques, biochemistry, genetic analysis, cell fractionation, microbiology, microscopy and imaging, embryogenesis, and plant and animal development. Introduction to experimental design, data analysis and display, and scientific writing. Prerequisite: Concurrently with or after BIOL 101, 102, and 103, or equivalent performance on the placement exam, or by permission of instructor.
MCDB 201Lb. Molecular Biology Laboratory. Maria Moreno
M or W 1.30-5.30 Meets RP WR
Basic molecular biology training in a project-based laboratory setting. Experiments analyze gene function through techniques of PCR, plasmid and cDNA cloning, DNA sequence analysis, and protein expression and purification. Instruction in experimental design, data analysis, and interpretation. For freshmen and sophomores. Concurrently with or after MCDB 200. Special registration procedures apply. Interested students must contact the instructor and attend an organizational meeting during the first week of classes.
MCDB 203La. Laboratory for Genetics. Iain Dawson, William Leiserson
MT or W 1.45-5.00
Introduction to laboratory techniques used in genetic analysis. Different genetic model organisms - bacteria, yeast, Drosophila, and Arabidopsis - are used to provide practical experience with various classical and molecular genetic techniques including cytogenetics, mutagenesis and mutant analysis, recombination and gene mapping, isolation and manipulation of DNA, and DNA sequence analysis. Concurrently with or after MCDB 202a.
MCDB 241Lb. Laboratory for Biology of Reproduction and Development. Mary Klein
TWTh 1.30-5.00
Laboratory investigation of reproductive and developmental processes. Emphasis on mammalian reproduction and embryonic development in classic vertebrate and invertebrate systems. Topics include gametogenesis, ovulation, hormonal control of reproduction, and investigation of embryogenesis in the frog and the fruit fly Drosophila. Enrollment limited. Concurrently with or after MCDB 210b or 240b. Not open to freshmen. Special registration procedures apply. Students must consult the instructor prior to the first week of classes.
MCDB 291Lb. Laboratory for Microbiology. Iain Dawson
TTh 2.30-5.20
Practical approaches used when working with microbes, primarily bacteria. Topics include microscopy, culture techniques, biochemical/metabolic assays, and basic environmental and medical microbiology. Concurrently with or after MCDB 290b. Electronic permission key required; students should contact the instructor.
MCDB 301La/MB&B 251La. Laboratory for Biochemistry. William Konigsberg, Aruna Pawashe, Alan Garen
HTBA
An introduction to current experimental methods in molecular biology. After or concurrently with MB&B 200a or 300b. Limited enrollment. Preregistration required; e-mail Aruna Pawashe and William Konigsberg prior to the first week of classes.
MCDB 303Lb. Advanced Molecular Biology Laboratory. Maria Moreno, Kenneth Nelson
Tu 2.30-3.45
Lab - W 1.00-4.00
A laboratory course that provides advanced biology research skills. Weekly workshops focus on good laboratory practice, advanced molecular biology topics, experimental design, data analysis and display, reading of primary literature, scientific presentations, and scientific writing skills. Application of these skills in project-based laboratory training sponsored by a faculty member. For juniors who have completed MCDB 121L or 201L and are planning their senior research projects. No research laboratory experience required. Special registration procedures apply. Interested students must contact the instructors and attend an organizational meeting in October 2012.
MCDB 321LaG. Laboratory for Neurobiology. Haig Keshishian, Robert Wyman
T or W 1.30- 5.30
Optional laboratory. Introduction to the neurosciences. Projects include the study of neuronal excitability, sensory transduction, CNS function, synaptic physiology, and neuroanatomy. Concurrently with or after MCDB 320a.
*MCDB 341Lb. Laboratory in Electron Microscopy. Barry Piekos
T or W 1.30-4.30
Techniques in light and electron microscopy. Enrollment limited; preference given to MCDB and MB&B majors; students must devote two to three additional laboratory hours per week. Students should contact the instructor prior to the first week of classes. After or concurrently with MCDB 205b.
*MCDB 342La. Laboratory in Nucleic Acids I. Kenneth Nelson
TTh 1.30-4.30
A project from a research laboratory within the MCDB department, using many of the technologies from molecular and cell biology. Laboratories meet twice a week for the first half of the term. With or after MCDB 202a, 205b, or 300b. Enrollment limited. Special registration procedures apply. Students must consult the instructor prior to the first week of classes.
*MCDB 343La. Laboratory in Nucleic Acids II. Kenneth Nelson
TTh 1.30-4.30
Continuation of MCDB 342La to more advanced methods and techniques in molecular and cell biology, including projects such as making and screening cDNA libraries or microarray screening and analysis. Laboratories meet twice a week for the second half of the term. Prerequisite: MCDB 342La or with permission of instructor. Enrollment limited. Special registration procedures apply. Students must consult the instructor prior to the first week of classes.
*MCDB 344Lb. Experimental Techniques in Cellular Biology. Joseph Wolenski
MW 1.30-6.30
A problems-based approach to questions in cell and molecular biology, with emphasis on experimental strategies and techniques. Topics include SDS-PAGE, immunoblots, column chromatography, mammalian cell culture, cell fractionation, light microscopy, drug studies, bacterial cultures, and methods of transfection and transformation. Prepares for MCDB 475a or b or 485a, 486b or 495a, 496b. Meets during January and February. Enrollment limited. Prerequisite: MCDB 205b. Special registration procedures apply. Students must contact the instructor in advance and are interviewed prior to enrollment.
*MCDB 345Lb. Experimental Strategies in Cellular Biology. Joseph Wolenski
MW 1.30-6.30
Continuation of MCDB 344Lb, with increased emphasis on experimental design and interpretation of data. Research projects involving protein purification are semi-independent. Focus on developing an independent research project in modern biomedical research. Students participate in journal discussions, formal seminars, and presentations of data to peers. Prepares for MCDB 475a or b or 485a, 486b or 495a, 496b. Enrollment limited. Meets during March and April. Prerequisite: MCDB 344Lb. Special preregistration procedures apply. Students must contact the instructor 12 months in advance.
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MCDB GENERAL ELECTIVE COURSES
NOTE: BIOL 101, 102, 103 and 104, or equivalent performance on the corresponding biological sciences placement examinations are prerequisites for MCDB courses numbered 200 and above.
STAT 101aG//MCDB 215a. Introduction to Statistics: Life Sciences. Jonathan Reuning-Scherer, Walter Jetz
TTh 1-2:15
Statistical and probabilistic analysis of biological problems, presented with a unified foundation in basic statistical theory. Problems are drawn from genetics, ecology, epidemiology, and bioinformatics.
A basic introduction to statistics, including numerical and graphical summaries of data, probability, hypothesis testing, confidence intervals, and regression. Each course focuses on applications to a particular field of study and is taught jointly by two instructors, one specializing in statistics and the other in the relevant area of application. The first seven weeks of classes are attended by all students in STAT 101–106 together, as general concepts and methods of statistics are developed. The remaining weeks are divided into field-specific sections that develop the concepts with examples and applications. Computers are used for data analysis. These courses are alternatives; they do not form a sequence and only one may be taken for credit. No prerequisites beyond high school algebra. May not be taken after STAT 100 or 109.
Students enrolled in STAT 101–106 who wish to change to STAT 109, or those enrolled in STAT 109 who wish to change to STAT 101–106, must submit a course change notice, signed by the instructor, to their residential college dean by Friday, September 28. The approval of the Committee on Honors and Academic Standing is not required.
*MCDB 230b/*MB&B 230b. Rain Forest Expedition and Laboratory. Scott Strobel, Carol Bascom-Slack, Kaury Kucera
MWF 10.30-11.20
Preparation for a two-week expedition to one of the world’s rain forests during spring break and for a ten-week summer laboratory experience using samples collected during the expedition. Integrated topics draw on the fields of ecology, microbiology, chemistry, pharmacology, molecular biology, and bioinformatics. Students participate in an original scientific project from field biology to natural product characterization. After one year of introductory biology or equivalent; after or concurrently with one term of organic chemistry. Limited enrollment. Funding for major travel expenses and summer research provided.
MCDB 240b. Biology of Reproduction. Hugh Taylor, Mary Klein
MWF 10.30-11.20
Introduction to reproductive biology, with emphasis on human reproduction: development and hormonal regulation of reproductive systems; sexuality, fertilization, and pregnancy; modern diagnosis and treatment of reproductive and developmental disorders; social and ethical issues. Preference to upperclassmen and to students who have completed MCDB 120a or 200b or higher. Prerequisite: BIOL 101, 102, and 103, or equivalent performance on the corresponding biological sciences placement examinations, or a score of 5 on the Advanced Placement test in Biology, or a score of 710 or above on the SAT Biology M test.
MCDB 290b. Microbiology. Christine Jacobs-Wagner, Carol Bascom-Slack
TTh 1.00-2.15
Cell structure of microorganisms, bacterial genetics, microbial evolution and diversity, microbial development, microbial interaction, chemotaxis and motility, gene regulation, microbial genomics, host defense systems, infectious diseases, viruses, and biological weapons. Prerequisites: BIOL 101, 102, and 103, or equivalent performance on the corresponding biological sciences placement examinations; two terms of organic chemistry; one term of biochemistry, cell biology, or genetics; or with permission of instructor.
MCDB 310aG/BENG 350aG. Physiological Systems. Mark Saltzman, Emile Boulpaep
MWF 9.25-10.15
Regulation and control in biological systems, emphasizing human physiology and principles of feedback. Biomechanical properties of tissues emphasizing the structural basis of physiological control. Conversion of chemical energy into work in light of metabolic control and temperature regulation. Prerequisites: CHEM 113 or 115 or PHYS 180a and 181b, <MCDB 120a>, or BIOL 101 and 102.
MCDB 315b. Biological Mechanisms of Reaction to Injury. Joseph Madri, Michael Kashgarian, Jon Morrow, Jeffrey Sklar, A. Brian West
TTh 11.35-12.50 Meets RP
Human biology and disease as a manifestation of reaction to injury. Organ structure and function, cell injury, circulatory and inflammatory responses, disordered physiology, and neoplasia. Enrollment limited; preference given to junior and senior majors in MCDB or MB&B. Prerequisite: MCDB 205b or 300b or 310a.
MCDB 320aG. Neurobiology. Haig Keshishian, Paul Forscher
MWF 11.35-12.25
The excitability of the nerve cell membrane as a starting point for the study of molecular, cellular, and intercellular mechanisms underlying the generation and control of behavior. After a year of chemistry; a course in physics is strongly recommended.
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MCDB SPECIAL ELECTIVE COURSES
[MCDB 356a. Experimental Strategies in Molecular Cell Biology]
[MCDB 361bG/AMTH 465b. Systems Modeling in Biology]
*MCDB 370bG. Biotechnology. Xing-Wang Deng, Kenneth Nelson, Farren Isaacs, Joseph Wolenski
MW 11.35-12.50
The principles and applications of cellular, molecular, and chemical techniques that advance biotechnology. Topics include the most recent tools and strategies used by government agencies, industrial labs, and academic research to adapt biological and chemical compounds as medical treatments, as industrial agents, or for the further study of biological systems. Prerequisites: MCDB 200b or 202a or 300b.
*MCDB 375b G. Advances in Plant Molecular Biology. Vivian Irish
M 7.00-8.50
Discussion and critical evaluation of selected research papers emphasizing recent advances in plant molecular biology. Topics include molecular genetic approaches to dissecting signaling events, pattern formation, epigenetic control of plant growth, and plant biotechnology. Focus on higher plants and model plant systems. Intended for advanced students after completion of at least one MCDB core course or equivalent.
*MCDB 387b. The Eukaryotic Cell Cycle. Iain Dawson
T or Th 7.00-8.50 p.m.
The regulation and coordination of the eukaryotic cell cycle examined by means of a detailed critique of primary literature. Particular attention to the processes of development, differentiation, and oncogenic disease. Enrollment limited, with preference to juniors and seniors. Prerequisites: BIOL 101, 102, and 103, or equivalent performance on the corresponding biological sciences placement examinations; MCDB 202 or 205. Electronic permission key required. Students must contact the instructor prior to the first week of classes.
[MCDB 410a G. Molecular Basis of Development]
MCDB 415b G. Cellular and Molecular Physiology. Emile Boulpaep, Frederick Sigworth
MWF 9.25-10.15
Study of the processes that transfer molecules across membranes. Topics include the different classes of molecular machines that mediate membrane transport. Emphasis on interactions among transport proteins in determining the physiologic behaviors of cells and tissues. Intended for seniors majoring in the biological sciences. Recommended preparation: MCDB 205b, 310a, 320a, or permission of instructor.
MCDB 425a G/MB&B 425a G. Basic Concepts of Genetic Analysis. Tian Xu, Lynn Cooley, Tae-Hoon Kim, Michael Koelle, Richard Lifton
MW 11.35-12.50
An examination of the universal principles of genetic analysis in eukaryotes. Reading and analysis of primary papers illustrating the best of genetic analysis in the study of a variety of biological issues. Focus on the concepts and logic underlying modern genetic analysis. Prerequisite: MCDB 202a or equivalent.
MCDB 430a G. Biology of the Immune System. Carla Rothlin, Tian Chi, Joseph Craft, Peter Cresswell, Kevan Herold, Akiko Iwasaki, Ruslan Medzhitov, Eric Meffre, Joao Pedro Pereira, David Schatz, Mark Shlomchik
MWF 9.25-10.15
The development of the immune system. Cellular and molecular mechanisms of immune recognition. Effector responses against pathogens; autoimmunity, immunodeficiency, HIV/AIDS. After MCDB 300b.
*MCDB 435a. Landmark Papers in Cell Biology. Joel Rosenbaum, Mark Mooseker
2 HTBA
Discussion and critical evaluation of selected research papers that were important in determining the directions of modern cell biological research. Emphasis on the nature of the problem, evaluation of experimental approaches and results, and the authors’ interpretation of the results. Students should contact the instructor prior to the first week of classes. Prerequisites: courses in cell biology, biochemistry and genetics, or permission of instructor.
*MCDB 440b G. Brain Development and Plasticity. Weimin Zhong, Sreeganga Chandra
MW 2.30-3.45
Recent advances in scientific understanding of brain development and plasticity, including neuronal determination, axon guidance, synaptogenesis, and developmental plasticity. Prerequisite: BIOL 101, 102, 103, and 104, or equivalent performance on the corresponding biological sciences placement examinations; MCDB 320 or permission of instructor.
MCDB 450b. The Human Genome. Stephen Dellaporta
M 3.30-5.30
A focus on the primary scientific literature covering the principles of genomics and its application to the investigation of complex human traits and diseases. Topics include the technology of genome sequencing and resequencing, the characterization of sequence and structural variation in human populations, haplotype and linkage disequilibrium analysis, genome-wide association studies, the comparative genomics of humans and our closest relatives, and personalized genomics and medicine. Enrollment limited to 15. Students should contact the instructor prior to the first week of classes. Prerequisite: MCDB 202; a course in statistics is strongly recommended.
MCDB 452aG/CPSC 452a/MB&B 452aG. Bioinformatics: Practical Application of Simulation and Data Mining. Mark Gerstein
MW 1.00-2.15
Techniques in data mining and simulation applied to bioinformatics, the computational analysis of gene sequences, macromolecular structures, and functional genomics data on a large scale. Sequence alignment, comparative genomics and phylogenetics, biological databases, geometric analysis of protein structure, molecular-dynamics simulation, biological networks, microarray normalization, and machine-learning approaches to data integration. Prerequisites: MB&B 301b and MATH 115, or permission of instructor.
[*MCDB 460bG. Cell Biology of the Neuron]
MCDB 482a Advanced Seminar in Cell Biology: Intracellular Signal Transduction. Craig Crews
M 7.00-8.50 p
Discussion of intracellular signal transduction pathways. Detailed critique of experimental approaches, controls, results, and conclusions of selected current and classic papers in this field.
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MCDB
RESEARCH AND TUTORIALS
*MCDB 470a or b. Tutorial in MCDB. Douglas Kankel
HTBA
Individual or small-group study for qualified students who wish to investigate a broad area of experimental biology not presently covered by regular courses. A student must be sponsored by a Yale faculty member, who sets the requirements. The course must include one or more written examinations and/or a term paper. This is intended to be a supplementary course and, therefore, to have weekly or biweekly discussion meetings between the student and the sponsoring faculty member. To register, the student must prepare a form, available in the office of the director of undergraduate studies, and a written plan of study with bibliography, approved by the adviser. The form and proposal must be uploaded to the Classes server or submitted to the course instructor in 754 KBT by Friday, September 10, for the fall term and Tuesday, January 18, for the spring term. The final paper is due in the hands of the sponsoring faculty member, with a copy to the course instructor, by the beginning of reading period. In special cases, with approval of the director of undergraduate studies, this course may be elected for more than one term, but only one term will count as an elective for the major. Additional sections offered in Beijing, China, under the supervision of Xing-Wang Deng. See under Peking University-Yale University Joint Undergraduate Program.
MCDB 475a or b. Research. Staff
HTBA
Research projects under faculty supervision, ordinarily taken to fulfill the senior requirement. This course may be taken before the senior year, but it cannot substitute for other requirements. Students are expected to spend approximately ten hours per week in the laboratory, and to make presentations to students and advisers at monthly section meetings. Written assignments include a short research proposal summary, at the beginning of the term, approved by the Yale faculty sponsor and the instructor in charge of the course. A final research report is required at the end of the term, before a grade is given. Seniors taking this course to fulfill the senior requirement must give an oral presentation of their research at the end of the term. Students who take this course more than once must reapply each term; students planning to conduct two terms of research should consider enrolling in MCDB 485a, 486b. Students should line up a research laboratory during the term preceding the research. Guidelines for the course should be obtained from the office of the director of undergraduate studies or downloaded from the Classes server. Written proposals are due Friday, September 7, for the fall term and Tuesday, January 15, for the spring term. Fulfills the senior requirement for the B.A. degree if taken in the senior year.
*MCDB 485a and 486b. Research in MCDB. Staff
HTBA Credit/Year Only
Individual two-term laboratory research projects under the supervision of a faculty member. Students are expected to spend ten to twelve hours per week in the laboratory, and to make presentations to students and advisers at monthly discussion groups. Written assignments include a short research proposal summary due at the beginning of the first term, a grant proposal due at the end of the first term, and a research report summarizing experimental results due at the end of the second term. Students are also required to present their research in either the fall or the spring term. A poster session is held at the end of the spring term. Students should line up a research laboratory during the term preceding the research. Guidelines for the course should be obtained from the office of the director of undergraduate studies or downloaded from the Classes server. Written proposals are due Friday, September 7, 2012. Fulfills the senior requirement if taken in the senior year. Additional sections offered in Beijing, China, under the supervision of Xing-Wang Deng. See under Peking University–Yale University Joint Undergraduate Program.
*MCDB 495a and 496b. Intensive Research in MCDB. Staff
HTBA Credit/Year Only
Qualified students may undertake directed research in some field of biology during the senior year. Before registering for this course, the student must be accepted for a research project by a Yale faculty member with a research program in experimental biology and obtain the approval of the instructor in charge of the course. Students spend approximately twenty hours per week in the laboratory, and make written and oral presentations of their research to students and advisers. Written assignments include a short research proposal summary due at the beginning of the first term, a grant proposal due at the end of the first term, and a research report summarizing experimental results due at the end of the second term. Students must attend a minimum of three research seminar sessions (including their own) per term. Students are also required to present their research during both the fall and spring terms. A poster session is held at the end of the spring term. Guidelines for the course are covered in detail in an information sheet that students should obtain from the office of the director of undergraduate studies early in the final term of the junior year. A written proposal must be submitted by Friday, September 7, 2012. Fulfills the senior requirement and leads to the B.S. Intensive major.
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BS/MS COURSES
The following courses are required for students in the joint B.S./M.S. Program with Yale College:
MCDB 585b. Research in MCDB for B.S./M.S. Candidates. Douglas Kankel
HTBA
A two-credit course taken in the third-to-last term (typically the second term of the junior year). At the start of this course, each student forms a committee composed of their adviser and two faculty members that meets to discuss the research project. At the end of this course, students complete a detailed prospectus describing their thesis project and the work completed thus far. The committee evaluates an oral and written presentation of this prospectus; the evaluation determines whether the student may continue in the combined program.
MCDB 595. Intensive in MCDB for B.S./M.S. Candidates. Douglas Kankel
HTBA
A four-credit, yearlong course (two credits each term) that is similar to MCDB 495a, 496b and is taken during the senior year. During this course, students give an oral presentation describing their work. At the end of the course, a student is expected to present his or her work to the department in the form of a poster presentation. In addition, the student is expected to give an oral thesis defense, followed by a comprehensive examination of the thesis conducted by the thesis committee. Upon successful completion of this examination, as well as other requirements, the student is awarded the combined B.S./M.S. degree.
With permission of the instructor, advanced undergraduates may take graduate courses for credit. If you are interested in one of these consult the instructor and you will need to fill out a special form that should be available in your college dean's office.
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MCDB GRADUATE COURSES: 2012 - 2013
MCDB 500bU/MB&B 500bU. Biochemistry. Ronald Breaker, Donald Engelman, Nicole Clay
MWF 9.25-10.15
An introduction to the biochemistry of animals, plants, and microorganisms, emphasizing the relations of chemical principles and structure to the evolution and regulation of living systems.
[MCDB 505a/GENE 705a/MB&B 705aU. Molecular Genetics of Prokaryotes.]
MCDB 517b/ENAS 517b/MB&B517b/Phys 517b/MCDB 517b. Methods and Logic in Interdisiplinary Research. Lynne Regan, Enrique De La Cruz, Eric Dufresne, Thierry Emonet, Paul Forscher, Megan King, Michael Levene, Simon Mochrie, Corey O’Hern, Thomas Pollard, Christine Jacobs-Wagner, Elizabeth Rhoades, Corey Wilson, and Staff.
MW 5.00-7.00
This half-term IGPPEB class is intended to introduce students to integrated approaches to research. Each session is led by faculty with complementary expertise and discusses papers that use different approaches to the same topic (for example, physical and biological or experiment and theory). Counts as 0.5 credit toward graduate course requirements. Required for students in IGPPEB.
MCDB 530aU/IBIO 530a. Biology of the Immune System. Carla Rothlin, Tian Chi, Joseph Craft, Peter Cresswell, Kevan Herold, Akiko Iwasaki, Ruslan Medzhitov, Eric Meffre, Joao Pedro Pereira, David Schatz, Mark Shlomchik
MWF 9.25-10.15
The development of the immune system. Cellular and molecular mechanisms of immune recognition. Effector responses against pathogens; autoimmunity, immunodeficiency, HIV/AIDS.
MCDB 550aU/C&MP 550aU/ENAS 550aU. Physiological Systems. Emile Boulpaep, W. Mark Saltzman
MWF 9.25-10.15
The course develops a foundation in human physiology by examining the homeostasis of vital parameters within the body, and the biophysical properties of cells, tissues, and organs. Basic concepts in cell and membrane physiology are synthesized through exploring the function of skeletal, smooth, and cardiac muscle. The physical basis of blood flow, mechanisms of vascular exchange, cardiac performance, and regulation of overall circulatory function are discussed. Respiratory physiology explores the mechanics of ventilation, gas diffusion, and acid-base balance. Renal physiology examines the formation and composition of urine and the regulation of electrolyte, fluid, and acid-base balance. Organs of the digestive system are discussed from the perspective of substrate metabolism and energy balance. Hormonal regulation is applied to metabolic control and to calcium, water, and electrolyte balance. The biology of nerve cells is addressed with emphasis on synaptic transmission and simple neuronal circuits within the central nervous system. The special senses are considered in the framework of sensory transduction. Weekly discussion sections provide a forum for in-depth exploration of topics. Graduate students evaluate research findings through literature review and weekly meetings with the instructor.
[MCDB 551aU. Experimental Strategies in Molecular Cell Biology]
[MCDB 555aU. Molecular Basis of Development]
MCDB 560bu/C&MP 560bu/ENAS 570bu. Cellular and Molecular Physiology: Molecular Machines in Human Disease. Emile Boulpaep, Fred Sigworth
MWF 9:25–10:15
The course focuses on understanding the processes that transfer molecules across membranes at the cellular, molecular, biophysical, and physiologic levels. Students learn about the different classes of molecular machines that mediate membrane transport, generate electrical currents, or perform mechanical displacement. Emphasis is placed on the relationship between the molecular structures of membrane proteins and their individual functions. The interactions among transport proteins in determining the physiologic behaviors of cells and tissues are also stressed. Molecular motors are introduced and their mechanical relationship to cell function is explored. Students read papers from the scientific literature that establish the connections between mutations in genes encoding membrane proteins and a wide variety of human genetic diseases.
MCDB 561bU/AMTH 665bU/PHYS 529b. Systems Modeling in Biology. Thierry Emonet, Steven Kleinstein, Xiao-Jing Wang, Steven Zucker
TTh 2.30-3.45
An introduction to the techniques of integrating knowledge from mathematics, physics, and engineering into the analysis of complex living systems. Use of these techniques to address key questions about the design principles of biological systems. Discussion of experiments and corresponding mathematical models. Reading of research papers from the literature. Students build their own models using MATLAB.
MCDB 570bU. Biotechnology. Xing-Wang Deng, Farren Isaacs, Kenneth Nelson, Joseph Wolenski
MW 11.35-12.50
The principles and applications of cellular, molecular, and chemical techniques that advance biotechnology. Topics include the most recent tools and strategies used by government agencies, industrial labs, and academic research to adapt biological and chemical compounds as medical treatments, as industrial agents, or for the further study of biological systems.
MCDB 591b/ENAS 991b/MBB 591b/PHYS 991b, Integrated Workshop. Lynne Regan, Eric Dufresne, Thierry Emonet, Paul Forscher, Simon Mochrie.
This required course for students in IGPPEB involves hands-on laboratory modules with students working in pairs. A biology student is paired with a physics or engineering student; a computation/theory student is paired with an experimental student. The modules are devised so that a range of skills are acquired, and students learn from each other.
MCDB 602a/CBIO 602a/MB&B 602a. Molecular Cell Biology. Sandra Wolin, Thomas Melia, Thomas Pollard, Michael Caplan, Craig Crews, Pietro De Camilli, Haifan Lin, Joseph Madri, Mark Mooseker, James Rothman, Megan King
MW 1:45–3.00
A comprehensive introduction to the molecular and mechanistic aspects of cell biology for graduate students in all programs. Emphasizes fundamental issues of cellular organization, regulation, biogenesis, and function at the molecular level.
MCDB 603a/CBIO 603a. Seminar in Molecular Cell Biology. Sandra Wolin, Thomas Melia, Thomas Pollard, Michael Caplan, Craig Crews, Pietro De Camilli, Joseph Madri, Mark Mooseker, James Rothman, Megan King
Th 9.00–11.00
A graduate-level seminar course in modern cell biology. The class is devoted to the reading and critical evaluation of classical and current papers. The topics are coordinated with the MCDB 602a lecture schedule. Concurrent or previous enrollment in MCDB 602a is required.
MCDB 625aU/GENE 625a/MB&B 625aU. Basic Concepts of Genetic Analysis. Tian Xu, Lynn Cooley, Tae-Hoon Kim, Michael Koelle, Richard Lifton
MW 11.35-12.50
The universal principles of genetic analysis in eukaryotes are discussed in lectures. Students also read a small selection of primary papers illustrating the very best of genetic analysis and dissect them in detail in the discussion sections. While other Yale graduate molecular genetics courses emphasize molecular biology, this course focuses on the concepts and logic underlying modern genetic analysis.
MCDB 630b/MB&B 630b Biochemical and Biophysical Approaches in Molecular and Cellular Biology. Thomas Pollard, Enrique De La Cruz, Anna Pyle
TTh 2.30–3.45
This graduate course introduces the theory and application of biochemical and biophysical methods to study the structure and function of biological macromolecules. The course considers the basic physical chemistry required in cellular and molecular biology but does not require a previous course in physical chemistry. One class per week is a lecture introducing a topic. The second class is a discussion of one or two research papers utilizing those methods.
MCDB 660a. Structure, Function, and Development of Vascular Plants. Graeme Berlyn
MW 4.00-5.20
Morphogenesis and adaptation of vascular plants considered from seed formation and germination to maturity. Physiological and developmental processes associated with structural changes in response to environment discussed from both a phylogenetic and an adaptive point of view.
MCDB 670b. Advanced Seminar in Biochemistry and Genetics. Sid Altman, Ronald Breaker, Frank Slack
W 1.30-3.30
New aspects of the molecular biology of RNA, ribonucleoproteins, and prions. Topics include the localization and function of RNA and ribonucleoproteins, siRNAs and microRNAs; the role of RNA in dosage compensation, chromosome silencing, and gene regulation; novel ribozymes and RNA technology; prions. Discussion; involvement and attendance are required.
MCDB 677b/GENE 777b. Mechanisms of Development. Valerie Reinke, and Staff
M 9.00–10.15, F 2.30–3.45
An advanced course on the mechanisms of animal development focusing on the genetic specification of cell organization and identity during embryogenesis and somatic differentiation. The use of evolutionarily conserved signaling pathways to carry out developmental decisions in a range of animals is highlighted. Course work includes student presentations, critical analysis of primary literature, and a research proposal term paper.
MCDB 720aU/NBIO 720a/NSCI 720a. Neurobiology. Haig Keshishian, Paul Forscher
MWF 11.35-12.25
Examination of the excitability of the nerve cell membrane as a starting point for the study of molecular, cellular, and intercellular mechanisms underlying the generation and control of behavior.
MCDB 721LaU. Laboratory for Neurobiology. Haig Keshishian, Robert Wyman
T or W 1.30-5.30
Optional laboratory. Introduction to the neurosciences. Projects include the study of neuronal excitability, sensory transduction, CNS function, synaptic physiology, and neuroanatomy.
MCDB 735b/NSCI 504b. Seminar in Brain Development and Plasticity. Weimin Zhong
MW 2.30-3.45
Weekly seminars and discussion sessions to explore recent advances in our understanding of brain development and plasticity, including neuronal determination, axon guidance, synaptogenesis, and developmental plasticity.
MCDB 743b/GENE 743b/MB&B 743bU. Mark Hochstrasser, Anthony Koleske, Patrick Sung
TTh 11.35–12.50
Selected topics in transcriptional control, regulation of chromatin structure, mRNA processing, mRNA stability, RNA interference, translation, protein degradation, DNA replication, DNA repair, site-specific DNA recombination, somatic hypermutation. Prerequisite: biochemistry or permission of the instructor.
[MCDB 750a/CB&B 750a Core Topics in Biomedical Informatics]
MCDB 752bU/CB&B 752b/CPSC 752bU/MB&B 752bU. Bioinformatics: Practical Application of Simulation and Data Mining. Mark Gerstein
MW 1.00-2.15
Bioinformatics encompasses the analysis of gene sequences, macromolecular structures, and functional genomics data on a large scale. It represents a major practical application for modern techniques in data mining and simulation. Specific topics to be covered include sequence alignment, large-scale processing, next-generation sequencing data, comparative genomics, phylogenetics, biological database design, geometric analysis of protein structure, molecular-dynamics simulation, biological networks, normalization of microarray data, mining of functional genomics data sets, and machine learning approaches for data integration. Prerequisites: MB&B 301b and MATH 115a or b, or permission of the instructor.
MCDB 861bU. The Human Population Explosion. Robert Wyman.
MW 2.30-3.45
Global population growth in its human, environmental, and economic dimensions. Social and sociobiological bases of reproductive behavior. Population history and the causes of demographic change. Interactions of population growth with economic development and environmental alteration. Overconsumption of the rich and overpopulation of the poor. “Hot-button” issues surrounding fertility: contraception, abortion, infanticide, and the status of women.
MCDB 900a/CBIO 900a/GENE 900a. First-Year Introduction to Research and Rotations – Grant Writing and Scientific Communication. Frank Slack and Staff
M 4.00-5.30
Grant writing, scientific communication, and laboratory rotation talks for Molecular Cell Biology, Genetics, and Development track students.
MCDB 901b/CBIO 901b/GENE 901b First-Year Introduction to Research-Ethics: Scientific Integrity in Biomedical Resarch. Megan King
Th 4.00-5.30
Ethics and laboratory rotation talks for Molecular Cell Biology, Genetics, and Development track students.
MCDB 902a/903b. Advanced Graduate Seminar. Timothy Nelson, Matthew Rodeheffer
T 11.30-1.00
This course will allow students to hone their presentation skills through yearly presentation of their dissertation work. Two students will each give 30-minute presentations in each class session. Students will be required to present every year beginning their third year in the MCDB program. Each MCDB graduate student will be required to attend at least 80% of the class sessions. Two faculty members will co-direct the course, attend the seminars, and provide feedback to the students.
MCDB 911a,/CBIO 911a/GENE 911a First Laboratory Rotation Carl Hashimoto and faculty
HBTA
First laboratory rotation for Molecular Cell Biology, Genetics, and Development track students.
MCDB 912b/ CBIO 912b/GENE 912b, Second Laboratory Rotation Valerie Reinke and faculty.
HTBA
Second laboratory rotation for Molecular Cell Biology, Genetics, and Development track students.
MCDB 913b /CBIO 913a/GENE 913b, Third Laboratory Rotation Frank Slack and faculty
HTBA
Third laboratory rotation for Molecular Cell Biology, Genetics, and Development track students.
MCDB 950a and 951b. Second-Year Research. By arrangement with Staff.
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Updated: August 15, 2012
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